While there is much accumulated experience with and well-established procedures and contracting processes for engaging academic and medical experts in the work of life science companies, patients, care partners, and patient advocates bring a different type of expertise to and expectations for interactions. This course will review ethical, legal, and regulatory requirements for patient contact and engagement, as well as emerging points of consensus about fair practices for engaging patients, care partners, and patient advocates, including non-disclosure, privacy, compensation, non-exclusivity, and independence.